KAT5 Antibody

$295.00

Background

KAT5 Antibody: KAT5 belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and non-histone proteins. KAT5 has been shown to play a role in DNA repair and apoptosis and is thought to play an important role in signal transduction and autophagy.

 

Description
KAT5 Antibody
Western blot analysis of KAT5 in human brain tissue lysate with KAT5 antibody at 1 μg/mL.

 

 

 

 

 

 

 

 

 

 

 

 

Specifications

Additional Names
KAT5 Antibody: lysine acetyltransferase 5, K-acetyltransferase 5, lysine acetyltransferase 5, HIV-1 Tat interactive protein 60kDa, HTATIP, HTATIP1, TIP, TIP60, cPLA2 interacting protein, cPLA2, ESA1, PLIP
Storage
KAT5 antibody can be stored at 4ËšC for three months and -20ËšC, stable for up to one year.
Reference

  • Kamine J, Elangovan B, Subramanian T, et al. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 1996; 216:357-66.
  • Kimura A and Horikoshi M. Tip60 acetylates six lysines of a specific class of core histones in vitro. Genes Cells 1998; 3:789-800.
  • Ikura T, Ogryzko VV, Grigoriev M, et al. Involvement of the TIP70 histone acetylase complex in DNA repair and apoptosis. Cell 2000; 102:463-73.
  • Lin SY, Li TY, Liu Q, et al. GSK3-TIP60-ILK1 signaling pathway links growth factor deprivation to autophagy. Science 2012; 336:477-81.]
Formulation
Physical State: Liquid 

Concentration: 1 mg/mL
Protein GI Number
36287069
Protein Accession Number
NP_874369
Molecular Weight
Predicted: 51, 54, 56, 60 kDa 

Observed: 53 kDa
Disclaimer
This product is for research use only.
Tested Application
E, WB
Blocking Peptide
Cat. No. ZP-7339 - KAT5 Peptide
User Note
Optimal dilutions for each application to be determined by the researcher.
Conjugate
None
Purification
KAT5 Antibody is affinity chromatography purified via peptide column.
Clonality/Clone
This is a polyclonal KAT5 Antibody.
Isotype
IgG
Host
KAT5 antibody was raised in rabbit.

Please use anti-rabbit secondary antibodies.
Specificity
Multiple isoforms of KAT5 are known to exist.
Immunogen
KAT5 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KAT5.
Application
KAT5 antibody can be used for detection of KAT5 by Western blot at 1 - 2 μg/mL.
Buffer
KAT5 Antibody is supplied in PBS containing 0.02% sodium azide.
Species Reactivity
H, M, R

 


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